Online CBC Seminar

Os reenviamos un mensaje sobre el próximo CBC Seminar de la Universitat Pompeu Fabra.

La Junta Directiva de la SEPEX

Dear all,

We have the pleasure to announce a CBC Seminar on

THURSDAY, December 16, 2021, at 17:00 PM CET.

Anne Churchland 
from UCLA invited by Rubén Moreno Bote

will give a talk titled

Pyramidal cell types drive functionally distinct cortical activity patterns during decision- making

Abstract: To understand how cortical circuits generate complex behavior, it is crucial to investigate the cell types that comprise them. Functional differences across pyramidal neuron (PyN) types have been observed in sensory and frontal cortex, but it is not known whether these differences are the rule across all cortical areas or if different PyN types mostly follow the same cortex-wide dynamics. We used genetic and retrograde labeling to target pyramidal tract (PT), intratelencephalic (IT) and corticostriatal projection neurons and measured their cortex-wide activity. Each PyN type drove unique neural dynamics at a cortex-wide and within-area scale. Cortical activity and optogenetic inactivation during an auditory discrimination task also revealed distinct functional roles: all PyNs in parietal cortex were recruited during sensory stimulation but, surprisingly, PT neurons were most important for perception. In frontal cortex, all PyNs were required for accurate choices but showed distinct choice-tuning. Our results reveal that rich, cell-type-specific cortical dynamics shape perceptual decisions.

Some articles that you may want to read in preparation of the talk are here:

We look forward to «seeing» you all!

The CBC Seminar Series – Universitat Pompeu Fabra